Zach Galifianakis found success in the comedy world with his Comedy Central Presents special as well as his show Late World With Zach. He achieved a household when he appeared in The Hangover and its subsequent sequels.
He later starred in films Due Date, The Campaign, and Birdman. By the time he reached the Birdman premiere in 2014, Galifianakis showed off a very impressive weight loss.
He attributes cutting out alcohol and going for long walks for the majority of his weight loss.
Jessica Simpson was always known for her amazing body, and had brought back the Daisy Duke shorts after starring in The Dukes of Hazzard film. After a failed marriage to Nick Lachey, Jessica married once again, this time finding love with football player Eric Johnson.
While she went through two pregnancies, Simpson gained nearly 80 pounds. However, she managed to stun the world by not only dropping the weight but getting back in tip top shape with the help of Weight Watchers and a serious workout routine.
50 Cent was always well known for his buff and muscular physique. It was pretty common to see promotional photos and album covers feating a shirtless 50 Cent sporting his usual six pack and intimidatingly large biceps.
However, he shocked us all when he dropped an alarming amount of weight. Luckily, the extreme weight loss was only for his role in the 2013 film All Things Fall Apart, in which he played a football player that is diagnosed with cancer.